New York, New York
3DC

Vice President of Preclinical Development

US-NY-New York

Job ID: 2
Type: Regular Full-Time
# of Openings: 1
Category: Research & Development
3DC

Overview

Deerfield Discovery and Development, LLC (3DC) is the drug discovery and development arm of Deerfield Management Company, L.P. (“Deerfield”), an investment firm dedicated to advancing healthcare, and is engaged in drug discovery research in collaboration with faculty from top universities across the United States. 3DC plays a critical role in identifying and progressing early-stage therapeutics from scientific discovery through clinical proof of concept, via rigorous due diligence of proposals, and design and execution of relevant experiments for approved projects. 3DC partners closely with principal investigators in Deerfield’s academic collaboration network, corporate and CRO partners to progress projects to value inflection points, and partners with Deerfield’s investment colleagues to execute the optimal monetization strategy for each project.

3DC seeks an experienced Preclinical Development leader to support small and large molecule discovery and development programs across a range of therapeutic areas. The individual will significantly contribute to discovery phase lead identification and serve as the strategic and technical lead for DMPK and safety evaluations. A key aspect of the position will be to develop collaborative relationships with principal investigators and project teams and serve as subject matter expert for identification of potential liabilities to optimize compound developability properties. The individual will also provide input into the characterization of development candidates and strategy for IND enabling studies through clinical proof of concept, and possess a thorough understanding of regulatory agency expectations for IND preparation through clinical POC.

The VP, Preclinical Development will report directly to the CEO of 3DC and be part of a cross-functional leadership team, including leaders of Medicinal Chemistry, Biologics, Pharmacology, CMC and Clinical Development.

Responsibilities

Responsibilities and Duties

• Build a functional capability, including a high-performing team of internal experts and leveraging an external network of partners, to deliver industry-leading preclinical strategies to support candidate selection from Hit ID through clinical POC.

• Lead and oversee the development, execution and interpretation of preclinical studies to identify and mitigate risks, drive to go/no go decisions and generate value.
• Collaborates closely with other members of Deerfield’s leadership team to develop and implement overall strategy for new project candidates.
• Develop and manage relationships with academic partners.
• Identify external vendors for execution. Coordinate placement and monitoring of studies, and review of data.
• Partner with biology team members to understand the target and animal model. Contribute to development of a translational strategy for identification of biomarkers for clinical development.
• Integrate bioavailability and DMPK data to establish PK/PD relationships in support of early allometric scaling of human dose.

• Early identification of potential safety liabilities of chemical series and development of mitigation strategies to facilitate candidate selection. Estimation of safety margins based on available data.
• Leadership in the development of early, hypothesis driven evaluation of potential or observed toxicities. Proactive identification of potential risks and communication of impact to teams.
• Responsible for providing perspective to teams on impact of preclinical findings including clinical and regulatory implications.

Qualifications

Qualifications

• PhD in pharmacology, toxicology or related discipline and 15+ years of relevant experience including work in a biopharma environment
• In depth knowledge of PK, PKPD, in vitro and in vivo metabolism and toxicology as well as regulatory expectations for IND filings
• Ability to work effectively both independently and collaboratively in a dynamic, team-based environment
• Experience preparing INDs and participating in regulatory interactions including preparation of responses to regulatory agency questions
• Strong organizational ability to prioritize and deliver data in a timely manner
• Ability to work effectively with external CROs and collaborators with professionalism and discretion
• Strong interpersonal skills including oral and written communication skills
• Ability to attract exceptional and diverse scientific talent into the organization

3DC provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

PM18

#LI-DNI

PI

New York, New York
3DC

Vice President of Preclinical Development

US-NY-New York

Job ID: 2
Type: Regular Full-Time
# of Openings: 1
Category: Research & Development
3DC

Overview

Deerfield Discovery and Development, LLC (3DC) is the drug discovery and development arm of Deerfield Management Company, L.P. (“Deerfield”), an investment firm dedicated to advancing healthcare, and is engaged in drug discovery research in collaboration with faculty from top universities across the United States. 3DC plays a critical role in identifying and progressing early-stage therapeutics from scientific discovery through clinical proof of concept, via rigorous due diligence of proposals, and design and execution of relevant experiments for approved projects. 3DC partners closely with principal investigators in Deerfield’s academic collaboration network, corporate and CRO partners to progress projects to value inflection points, and partners with Deerfield’s investment colleagues to execute the optimal monetization strategy for each project.

3DC seeks an experienced Preclinical Development leader to support small and large molecule discovery and development programs across a range of therapeutic areas. The individual will significantly contribute to discovery phase lead identification and serve as the strategic and technical lead for DMPK and safety evaluations. A key aspect of the position will be to develop collaborative relationships with principal investigators and project teams and serve as subject matter expert for identification of potential liabilities to optimize compound developability properties. The individual will also provide input into the characterization of development candidates and strategy for IND enabling studies through clinical proof of concept, and possess a thorough understanding of regulatory agency expectations for IND preparation through clinical POC.

The VP, Preclinical Development will report directly to the CEO of 3DC and be part of a cross-functional leadership team, including leaders of Medicinal Chemistry, Biologics, Pharmacology, CMC and Clinical Development.

Responsibilities

Responsibilities and Duties

• Build a functional capability, including a high-performing team of internal experts and leveraging an external network of partners, to deliver industry-leading preclinical strategies to support candidate selection from Hit ID through clinical POC.

• Lead and oversee the development, execution and interpretation of preclinical studies to identify and mitigate risks, drive to go/no go decisions and generate value.
• Collaborates closely with other members of Deerfield’s leadership team to develop and implement overall strategy for new project candidates.
• Develop and manage relationships with academic partners.
• Identify external vendors for execution. Coordinate placement and monitoring of studies, and review of data.
• Partner with biology team members to understand the target and animal model. Contribute to development of a translational strategy for identification of biomarkers for clinical development.
• Integrate bioavailability and DMPK data to establish PK/PD relationships in support of early allometric scaling of human dose.

• Early identification of potential safety liabilities of chemical series and development of mitigation strategies to facilitate candidate selection. Estimation of safety margins based on available data.
• Leadership in the development of early, hypothesis driven evaluation of potential or observed toxicities. Proactive identification of potential risks and communication of impact to teams.
• Responsible for providing perspective to teams on impact of preclinical findings including clinical and regulatory implications.

Qualifications

Qualifications

• PhD in pharmacology, toxicology or related discipline and 15+ years of relevant experience including work in a biopharma environment
• In depth knowledge of PK, PKPD, in vitro and in vivo metabolism and toxicology as well as regulatory expectations for IND filings
• Ability to work effectively both independently and collaboratively in a dynamic, team-based environment
• Experience preparing INDs and participating in regulatory interactions including preparation of responses to regulatory agency questions
• Strong organizational ability to prioritize and deliver data in a timely manner
• Ability to work effectively with external CROs and collaborators with professionalism and discretion
• Strong interpersonal skills including oral and written communication skills
• Ability to attract exceptional and diverse scientific talent into the organization

3DC provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to religion, race, creed, color, sex, sexual orientation, alienage or citizenship status, national origin, age, marital status, pregnancy, disability, veteran or military status, predisposing genetic characteristics or any other characteristic protected by applicable federal, state or local law.

PM18

#LI-DNI

PI